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KMID : 1100220050040020068
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Dementia and Neurocognitive Disorders
2005 Volume.4 No. 2 p.68 ~ p.75
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Embryonic Stem Cell Therapy for Neurodegenerative Brain Diseases
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Roh Sung-Il
Lee Joo-Young
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Abstract
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Recent finding that neural stem cells exist, divide, and differentiate into neurons or glia in adult mammalian brain, has raised hope for the therapeutic application of stem cells for neurodegenerative brain diseases. This is because transplanted stem cells may functionally or pathophysiologically compensate for neural cell loss or stimulate endogenous neurogenesis in the injured brain. Since the reconstruction of a damaged brain would require a large graft of neural cells, the neural differentiation of stem cells (adult or embryonic) is very important in cell replacement therapy for brain disorders. We here make a brief description of stem cells, and review the methodological development of neural differentiation in embryonic stem cells. Moreover, the current application and obstacles of cell therapy for some brain diseases are also demonstrated.
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KEYWORD
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Cell replacement therapy, Neural differentiation, Self-renewal, Pluripotency
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