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KMID : 1100720120320020158
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Annals of Laboratory Medicine
2012 Volume.32 No. 2 p.158 ~ p.161
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A Case of Rosai-Dorfman Disease with Highly Elevated Serum Ferritin
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Rew Sung-Yoon
Jang Hee-Chang
Park Kyung-Hwa
Ahn Jae-Sook
Kim Ga-Eon
Choi Yoo-Duk
Jung Sook-In
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Abstract
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Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease is a rare disorder characterized by proliferation of distinctive histiocytes within lymph node sinuses and lymphatics, sometimes involving extranodal sites. However, clinical suspicion is difficult and there is also a lack of useful diagnostic markers for this disorder prior to histological confirmation. High elevation of serum ferritin is known to be a useful diagnostic marker for various hematologic diseases, including hemophagocytic lymphohistiocytosis and lymphoma. Here, we report a case of fever of unknown origin that presented along with highly elevated serum ferritin (5,780 ng/mL), and was finally diagnosed as Rosai-Dorfman disease by lymph node biopsy.
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KEYWORD
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Ferritin, Fever of unknown origin, Sinus histiocytosis with massive lymphadenopathy, Rosai-Dorfman disease
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