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KMID : 1100720120320040289
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Annals of Laboratory Medicine
2012 Volume.32 No. 4 p.289 ~ p.293
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MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia
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Seo Ja-Young
Lee Soo-Hyun
Kim Hee-Jin
Yoo Keon-Hee
Koo Hong-Hoe
Cho Yong-Gon
Choi Sam-Im
Kim Sun-Hee
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Abstract
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MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia.
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KEYWORD
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Precursor B-cell acute lymphoblastic leukemia, MYC gene rearrangement, Non-immunoglobulin partner
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