KMID : 1100720120320050362
|
|
Annals of Laboratory Medicine 2012 Volume.32 No. 5 p.362 ~ p.365
|
|
Detection of RUNX1-MECOM Fusion Gene and t(3;21) in a Very Elderly Patient Having Acute Myeloid Leukemia with Myelodysplasia-Related Changes
|
|
Yang Jeong-Seok
Cho Sun-Young Suh Jin-Tae Lee Hee-Joo Lee Woo-In Yoon Hwi-Joong Baek Sun-Kyung Park Tae-Sung
|
|
Abstract
|
|
|
An 87-yr-old woman was diagnosed with AML with myelodysplasia-related changes (AMLMRC). The initial complete blood count showed Hb level of 5.9 g/dL, platelet counts of 27 ¡¿109/L, and white blood cell counts of 85.33¡¿109/L with 55% blasts. Peripheral blood samples were used in all the tests, as bone marrow examination could not be performed because of the patient¡¯s extremely advanced age and poor general health condition. Flow cytometric analysis, chromosome analysis, FISH, and reverse transcriptase-PCR (RT-PCR) results indicated AML-MRC resulting from t(3;21) with the RUNX1-MECOM fusion gene. To our knowledge, this is the second most elderly de novo AML patient associated with t(3;21) to be reported.
|
|
KEYWORD
|
|
RUNX1, MECOM, t(3, 21), Acute myeloid leukemia, Myelodysplasia-related changes
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|