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KMID : 1100720140340010031
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Annals of Laboratory Medicine
2014 Volume.34 No. 1 p.31 ~ p.37
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The Drug Resistance Profile of Mycobacterium abscessus Group Strains from Korea
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Lee Seung-Heon
Yoo Hee-Kyung
Kim Seol-Hee
Koh Won-Jung
Kim Chang-Ki
Park Young-Kil
Kim Hee-Jin
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Abstract
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Background: Bacteria of the Mycobacterium abscessus group are the second most common pathogens responsible for lung disease caused by nontuberculous mycobacteria in Korea. There is still a lack of studies investigating the genetic mechanisms involved in a resistance to antibiotics other than clarithromycin. This study investigated the characteristics of drug resistance exhibited by M. abscessus clinical isolates from Korea.
Methods: We performed drug susceptibility testing for a total of 404 M. abscessus clinical strains. Subspecies were differentiated by molecular biological methods and examined for mutations in drug resistance-related genes.
Results: Of the 404 strains examined, 202 (50.00%), 199 (49.26%), and 3 (0.74%) strains were identified as M. abscessus, M. massiliense, and M. bolletii, respectively. Of the 152 clarithromycin-resistant strains, 6 possessed rrl mutations, while 4 of the 30 amikacin-resistant strains contained rrs mutations, and 5 of the 114 quinolone-resistant strains had gyr mutations. All mutant strains had high minimal inhibitory concentration values for the antibiotics.
Conclusions: Our results showed the distribution of the strains with mutations in drug resistance-related genes was low in the M. abscessus group. Furthermore, we performed drug susceptibility testing and sequence analyses to determine the characteristics of these genes in the M. abscessus group.
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KEYWORD
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Mycobacterium abscessus group, Drug resistance, Mutation
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