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KMID : 1100720190390060537
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Annals of Laboratory Medicine
2019 Volume.39 No. 6 p.537 ~ p.544
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Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016
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Park Dong-Chul
Kim Si-Hyun
Yong Dong-Eun
Suh In-Bum
Kim Young-Ree
Yi Jong-Youn
Song Won-Keun
Song Sae-Am
Moon Hee-Won
Lee Hae-Kyung
Park Kyoung-Un
Kim Sun-Joo
Jeong Seok-Hoon
Lee Jae-Hyeon
Jeong Joseph
Kim Yu-Kyung
Lee Mi-Ae
Cho Ji-Hyun
Kim Jong-Wan
Shin Kyeong-Seob
Hwang Sang-Hyun
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Abstract
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Background: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea.
Methods: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern.
Results: The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively.
Conclusions: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines.
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KEYWORD
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Streptococcus pneumoniae, Serotype, Antimicrobial resistance, Pneumococcal vaccine
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