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KMID : 1100820190090040263
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Laboratory Medicine Online
2019 Volume.9 No. 4 p.263 ~ p.268
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A Case of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia with IgM-κ and IgA-λ Biclonal Gammopathy
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Shin Woo-Yong
Bang Hae-In
Kim Ji-Eun
Park Ro-Jin
Shin Jeong-Won
Choi Tae-Youn
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Abstract
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Lymphoplasmacytic lymphoma (LPL) is a low-grade B-cell neoplasm, composed of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually involving bone marrow and sometimes lymph nodes or spleen. LPL with bone marrow involvement and an IgM monoclonal gammopathy of any concentration is designated as Waldenstrom macroglobulinemia (WM). LPL associated with non-IgM monoclonal gammopathy or biclonal gammopathy is rarely observed. LPL diagnosis was based on clinical, morphological, and immunophenotypic findings. Recently, the test for L265P mutation of the myeloid differentiation factor 88 (MYD88) gene has been helpful in the diagnosis of LPL. Here, we reported the first case of LPL/WM with IgM-κ/IgA-λ biclonal gammopathy in Korea.
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KEYWORD
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Lymphoplasmacytic lymphoma, Waldenstrom's macroglobulinemia, Myeloid differentiation factor 88, Multiple myeloma, Biclonal paraproteinemia
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