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KMID : 1100820200100010001
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Laboratory Medicine Online
2020 Volume.10 No. 1 p.1 ~ p.9
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Recommendations for the Use of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part I. Implementation and Management
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Lee Kyung-Hoon
Moon Soo-Young
Kim Se-Rim
Choi Hyun-Jung
Lee Sang-Guk
Park Hyung-Doo
Lee Soo-Youn
Song Sang-Hoon
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Abstract
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Many types of assays involving mass spectrometry have been developed and applied in clinics. However, mass spectrometry has not been widely implemented yet relative to other measurement methods, including biochemical assays, immunoassays, and molecular diagnostics. Despite its strong advantage as an analytical method, many laboratory physicians and clinical laboratories are unwilling to introduce it. Fundamental elements, such as instruments, reagents, facilities, skilled human resources are required to implement mass spectrometry. This review contains considerations for the introduction of liquid chromatography-mass spectrometry to support the clinical laboratories interested in or planning to implement mass spectrometry.
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KEYWORD
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Liquid chromatography-mass spectrometry (LC-MS), Clinical laboratory, Mass spectrometric assay
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