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KMID : 1101420160480010022
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Korean Journal of Clinical Laboratory Science
2016 Volume.48 No. 1 p.22 ~ p.29
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Relations between Normal Serum Gamma-glutamyltransferase and Risk Factors of Coronary Heart Diseases according to Age and Gender
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Kwon Se-Young
Na Young-Ak
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Abstract
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Serum gamma-glutamyltransferase (GGT) has been widely used as a marker of alcohol intake and liver failure. Recently, the relativity between GGT and various diseases has been identified with growing interest. In this study, we examined relativity between GGT value and risk factors of coronary heart diseases among those with normal GGT value, excluding heavy drinkers. Specifically, we compared the differences based on age and gender. Data from the 2011 KNHNES were used (N=3,619). When the subjects were categorized according to quartile based on the serum GGT levels, there was 10~20, 21~27, 28~38, 39~71 IU/L in men, and 6~12, 13~16, 17~22, 23~42 IU/L in women. The mean of most variables was the highest in the 4th quartile (Q4), however age and LDL Cholesterol were the highest in the 2nd quartile (Q2) in men. The FRS and 10-year CHD risk was the highest in the 2nd quartile in men, and the highest in the 4th quartile in women. Increased GGT was correspondingly linked with age in women but age was the highest in GGT in the 2nd quartile in men. In the 70’s, the highest Q1 and Q2 was in men and the highest Q3 and Q4 in women. Although GGT value was within the normal range, increased GGT showed correlation with various risk factors. The FRS and 10-year CHD risk showed different patterns according to age and gender along with increased GGT value.
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KEYWORD
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Gamma-glutamyltransferase, Framingham risk score, Coronary heart disease
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