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KMID : 1101620160270030158
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Perinatology
2016 Volume.27 No. 3 p.158 ~ p.161
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Risk Factors Associated Respiratory Insufficiency and Long-term Ventilator Support in Neonates with Omphalocele
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Kim Hyo-Won
Shin Seung-Hyun
Woo Hae-Kyung
Choi Eui-Kyung
Song In-Gu
Jung Young-Hwa
Shin Seung-Han
Kim Eu-Kyung
Kim Han-Suk
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Abstract
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Purpose: The objective of this study was to determine factors associated with respiratory insufficiency and long term ventilator-support in newborn with omphalocele.
Methods: Medical records of neonates with omphalocele in the neonatal intensive care unit (NICU) in Seoul National University Children's Hospital between April 2000 and March 2016 were reviewed retrospectively.
Results: A total of 44 neonates were enrolled. Infants intubated within 24 hours after birth (early intubated group, n=21) and not intubated within 24 hours after birth (late intubated group n=23) were compared. Duration of ventilator care, duration of total parenteral nutrition administration, duration of NICU stay and mortality rate were higher in the early intubated group. The early intubated group had lower gestational age, lower birth weight, lower 1min and 5min Apgar score and higher mortality rate with longer duration of mechanical ventilator support than late intubated group. Persistent pulmonary hypertension and small for gestational age were related to the duration of ventilator support.
Conclusion: It is important to predict and prevent of respiratory insufficiency and prolongation of invasive mechanical ventilation in neonates with omphalocele. It is needed to diagnose pulmonary hypertension and respiratory failure after birth in early stages. Further prospective large cohort studies are needed to determine the pathophysiology of respiratory insufficiency and ventilator dependency of neonates with omphalocele reducing morbidity.
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KEYWORD
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Omphalocele, Respiratory insufficiency, Pulmonary hypertension
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