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KMID : 1101620160270030190
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Perinatology
2016 Volume.27 No. 3 p.190 ~ p.193
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Ampicillin/Sulbactam-induced Hemolytic Anemia Manifested as Hyperbilirubinemia in a Preterm Infant
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Roh Joo-Hyung
Yun Hey-Suk
Park Hyun-Kyung
Lee Hyun-Ju
Kim Chang-Ryul
Han Tae-Hee
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Abstract
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A female was born at 36+5 weeks of gestation with a birth weight of 2,120 g. Apgar score was 7 at 1 minute and 9 at 5 minutes. Shortly after birth, tachypnea, chest retraction, and a severe build-up of oral secretions were noted. Her blood type was A+ and initial hemoglobin was 17.5 g/dl. Her mother was A+ blood type. Ampicillin/Sulbactam and gentamicin were started empirically. At 8th day of admission, laboratory results showed hemolytic anemia. Exchange transfusion was performed along with intravenous immunoglobulin and hydrocortisone. After 2 days, the patient's clinical and laboratory conditions improved. Column hemagglutination assay revealed that the patient's hemolysis was due to ampicillin/sulbactam.
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KEYWORD
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Ampicillin-sulbactam, Hemolytic anemia, Preterm infant
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