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KMID : 1101620160270040227
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Perinatology
2016 Volume.27 No. 4 p.227 ~ p.235
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Dose Brain MRI before Discharge at NICU Predict Neurodevelopmental Outcomes in Very Low Birth Weight Infants?
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Yoon Young-Mi
Jung Young-Hwa
Kim Ji-Young
Kim Hun-Min
Choi Chang-Won
Kim Beyong-Il
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Abstract
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Purpose: To test whether brain MRI can predict neurodevelopmental outcomes of very low birth weight (VLBW) infants in a single academic center.
Methods: This was a retrospective study of VLBW infants admitted to neonatal intensive care unit from January 2010 to December 2014. Infants who were taken brain MRI before discharge and followed-up at 12 or 24 months' corrected age (CA) were enrolled. The neurodevelopment outcomes included cerebral palsy (CP) and cognitive or motor delay on Bayley Scale of Infant Development-II.
Results: Of the 255 survivors at discharge, 182 (71.4%) had a brain MRI. Any abnormalities on brain MRI were predictive of CP (odds ratio [OR] 15.8, 95% confidence interval [CI] 1.9-128.1) and motor delay(OR 4.4, 95% CI 1.0-19.3) at 12 months' CA. Moderate to severe white matter abnormalities on brain MRI were significantly correlated with CP (OR 49.0, 95% CI 10.1-238.2) and moderate to severe motor delay (OR 8.3, 95% CI 1.2-56.7) at 12 months' CA, and CP (OR 43.8, 95% CI 6.4-299.8) at 24 months' CA. Moderate to severe white matter abnormalities on brain MRI were consistently associated with CP at 12 and 24 months' CA after adjustment for demographic and clinical variables and cranial ultrasonography findings (OR 800.5, 95% CI 6.9-92,665.7 at 12 months' CA, OR 52.0, 95% CI 1.3-2,168.2 at 24 months' CA).
Conclusion: Moderate to severe white matter abnormalities on brain MRI strongly predicted cerebral palsy at 12 months and 24 months' CA in VLBW infants.
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KEYWORD
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Infant, Premature, Magnetic resonance imaging, Neurodevelopmental outcomes
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