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KMID : 1101620170280040140
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Perinatology
2017 Volume.28 No. 4 p.140 ~ p.145
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Staphylococcus capitis Induced Late-onset Sepsis in Very Low Birth Weight Infants
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Kim In
Lim Gin-A
Hwang Eun-Ha
Oh Ki-Won
Jeong Joseph
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Abstract
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Objective: To determine the causative organisms of late-onset sepsis (LOS) and describe LOS induced by Staphylococcus capitis (S. capitis) in very low birth weight infants (VLBWI).
Methods: The medical records of VLBWI with blood culture proven LOS admitted to Ulsan University Hospital between January 2010 and December 2016 were investigated retrospectively.
Results: Among 329 VLBWI, 84 episodes of LOS occurred in 60 neonates (18.2%). Forty-two (50.0%) episodes were caused by coagulase-negative staphylococci (CoNS) and S. capitis and S. epidermidis were the leading organisms. S. capitis LOS developed in 21 VLBWI with 26 (30.9%) episodes. Necrotizing enterocolitis developed in 3 patients and 1 was diagnosed with infectious endocarditis. Six neonates died and death in 2 patients was directly related to S. capitis LOS. All episodes of S. capitis LOS demonstrated oxacillin and multi-drug resistance.
Conclusion: CoNS are the most common cause of LOS in VLBWI. In addition to S. epidermidis, S. capitis should be considered as an important emerging cause of LOS, as it is associated with severe morbidity and increased mortality in VLBWI.
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KEYWORD
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Staphylococcus capitis, Neonatal sepsis, Very-low-birth-weight infant
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