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KMID : 1101620180290010039
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Perinatology
2018 Volume.29 No. 1 p.39 ~ p.47
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The Effect of Acute Histologic Chorioamnionitis on Hematologic Profile of Preterm Fetuses
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Kang Hye-Sim
Park Jeong-Woo
Kim Hee-Sun
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Abstract
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Objective: To characterize the hematologic profile of preterm fetuses delivered spontaneously with acute histologic chorioamnionitis (HCA).
Methods: This was a retrospective cohort study. The relationship between the presence of acute HCA and the change of hematologic profile was examined in 109 singleton pregnant women who were admitted and delivered between 24?32 weeks of gestation. Cases without results of placental histologic examination, cord blood cell count, and the differential count were excluded. From the cord blood, hemoglobin concentration, hematocrit, mean corpuscular volume, total leucocyte count and the differential count, platelet count, normoblast count, and umbilical arterial pH were obtained. All the observed values were corrected for gestational age by calculating a ratio between the observed and mean expected value for gestational age.
Results: 1) The prevalence of acute HCA was 60.6% (66/109); 2) newborns with acute HCA had a higher median corrected leucocyte counts and corrected percentage of neutrophil in the differential count and a lower median corrected percentage of lymphocyte in the differential count than those without acute HCA; 3) neutrophilia was significantly frequent in newborns with acute HCA than in those without acute HCA; and 4) acute HCA was not associated with detectable changes in percentage of monocyte, eosinophil, basophil, and normoblast in the differential count, hemoglobin concentration, hematocrit, erythrocyte counts, mean corpuscular volume, platelet counts, or umbilical arterial pH.
Conclusion: The hematologic profile of preterm fetuses delivered spontaneously with acute HCA is characterized by significant changes in the total leucocyte count, neutrophil percentage, and lymphocyte percentage.
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KEYWORD
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Hematologic test, Preterm, Chorioamnionitis, Fetus
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