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KMID : 1101620180290020078
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Perinatology
2018 Volume.29 No. 2 p.78 ~ p.82
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Effectiveness of B-type Natriuretic Peptide in Caring for Preterm Infants
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Lee Na-Rae
Bae Mi-Hye
Han Young-Mi
Park Kyung-Hee
Byun Shin-Yun
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Abstract
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Objective: Volume and pressure loading of the ventricles are associated with increased plasma B-type natriuretic peptide (BNP) levels. Hemodynamically significant patent ductus arteriosus (hsPDA) is a risk factor for life-threatening conditions in preterm infants. We compared follow-up data such as echocardiograms, BNP levels, comorbidities, and prognosis in preterm infants with PDA, and investigated the relationship between maternal prenatal factors and BNP.
Methods: This single-center study performed between January 2015 and August 2016 included 63 preterm infants with a gestational age of <35 weeks. We retrospectively evaluated the BNP levels on postnatal day 1, 3, and 7, clinical features, treatment method for PDA, mortality, and maternal prenatal factors.
Results: Lower gestational age and smaller birth weight were associated with a higher incidence of hsPDA (P<0.01). Postnatal day 3 BNP levels were significantly higher in the hsPDA group. BNP levels were not associated with failure of medication in the hsPDA group. Postnatal day 1 BNP levels were associated with an abnormal umbilical artery flow (P=0.017), and deceleration in fetal non-stress test result (P=0.01) but not with other maternal states.
Conclusion: BNP levels are a useful predictive biomarker for hsPDA in preterm infants during the 3rd days of life; however, they do not help in decision-making regarding treatment. BNP levels on the 1st postnatal day showed a positive correlation with prenatal factors such as abnormal umbilical artery flow and deceleration in fetal NST result.
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KEYWORD
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Brain natriuretic peptide, Patent ductus arteriosus, Premature infant
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