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KMID : 1101620210320010012
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Perinatology
2021 Volume.32 No. 1 p.12 ~ p.17
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Iatrogenic Prelabor Premature Rupture of Membrane and Preterm Birth: an Experimental Mouse Study
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Wang Eun-Jin
Kim Ho-Yeon
Cho Geum-Joon
Hong Soon-Cheol
Oh Min-Jeong
Kim Hai-Joong
Ahn Ki-Hoon
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Abstract
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Objective: We aimed to investigate whether mouse mothers born prematurely give birth to preterm pups.
Methods: Sexually mature female C57BL/6 mice were used. To create the pPROM model, the fetal membranes of the right uterus were pierced using sterile 21- or 26-gauge needles on gestational day 15.5.
Results: The mean gestational duration of the first-generation pPROM model was 17.5 days. The mean gestational duration for the second-generation female mice born prematurely from the pPROM model was 19.8 days. The gestational duration between the first and second generations was significantly different (P<0.01). The average pup weight was greater in the third-generation mice than in the second-generation mice.
Conclusion: Mice born to pPROM model mice did not give birth to preterm pups. It appears that mother born prematurely through iatrogenic pPROM does not have preterm birth.
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KEYWORD
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Cervix, Iatrogenic prelabor premature rupture of membrane, Offspring, Prelabor premature rupture of membrane, Preterm birth
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