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KMID : 1104820170050020097
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Journal of Digestive Cancer Research
2017 Volume.5 No. 2 p.97 ~ p.104
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Model for Cancer Cachexia using C26 Adenocarcinoma-Induced Wasting Syndrome for Newer Therapeutic Approach
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Kang Eun-A
Park Jong-Min
Han Young-Min
Hong Sung-Pyo
Cho Joo-Young
Yoo In-Kyung
Oh Ji-Young
Hahm Ki-Baik
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Abstract
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Background: Cachexia is a multi?factorial syndrome presenting with chronic illness, decreases in body weight, and loss of adipose tissue and skeletal muscle, mostly in patients with advanced cancer and chronic wasting disease. Even after years of intensive researches, there remains no convincing therapy to prevent cancer cachexia.
Methods: In this in vivo study, we have established C26 adenocarcinoma-induced cancer cachexia model in mice to explore the underlying core changes in cytokine, signal transduction, and muscle wasting. The ultimate aim of establishing animal model is to find optimal therapeutics to mitigate cancer cachexia.
Results: We have administered C26 adenocarcinoma cells onto BALB/c mice and observed 4 weeks to assess the progression of cancer cachexia. Significant loss of weight accompanied with loss of appetite was noted. As C26 adenocarcinoma xenograft progressed, mortality was started from 3 weeks, accompanied with significant sarcopenia and decreased mice movement. Surges in TNF-α and IL-6 were noted with the commencement of cancer cachexia.
Conclusion: Using C26 adenocarcinoma cancer cachexia model, we can screen the optimal therapeutics to mitigate cancer cachexia, in which agents to modulate IL-6, TNF-α, and NF-κB were essential.
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KEYWORD
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Cancer cachexia, C26 adenocarcinoma, Weight loss, Myopathy, Anorexia
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