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KMID : 1130320080510050528
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Korean Journal of Pediatrics
2008 Volume.51 No. 5 p.528 ~ p.532
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Autoimmune hepatitis and thyroiditis associated with antituberculous medications
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Yu Seong-Keun
Kim Sa-Ra
Moon Jin-Soo
Kim Han-Seong
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Abstract
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Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case in Korea of drug-induced autoimmune hepatitis associated with thyroiditis and multiple autoantibodies that was induced by the antituberculous drugs isoniazid and rifampin.
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KEYWORD
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Toxic hepatitis, Autoimmune thyroiditis, Isoniazid, Rifampin
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