|
KMID : 1130320080510121359
|
|
Korean Journal of Pediatrics
2008 Volume.51 No. 12 p.1359 ~ p.1362
|
|
|
Availability of peripheral inserted central catheters in severe hemophilia patients with inhibitors
|
|
Park Young-Shil
|
|
|
Abstract
|
|
|
|
The most effective treatment strategy for patients with hemophilia is replacement therapy with FVIII or FIX concentrates, which usually requires long-term, uncomplicated venous access. However, central venous access device (CVADs, ports) insertion requires inpatient admission and general anesthesia, and presents some problems regarding health insurance coverage. Peripherally inserted central catheters (PICCs) were inserted in two severe hemophilia patients aged 7 and 11 years with high titers of inhibitors. They experienced frequent bleeding episodes and required replacement therapy, which eventually resulted in difficulty in acquiring venous line access. Factor VIII activity was below 1%, and inhibitor titers were 160 and 26.3 BU/ml. In an outpatient setting, PICC lines are easily placed by radiological guidance and require local anesthesia alone. PICC has been feasible, in particular, for hemophilia patients with frequent bleeding episodes.
|
|
|
KEYWORD
|
|
|
Hemophilia, Peripherally inserted central catheter
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|