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KMID : 1130320090520020176
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Korean Journal of Pediatrics
2009 Volume.52 No. 2 p.176 ~ p.180
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The association between serum IGF-1 and neonatal growth and disease in a NICU
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Kim Jung-Ok
Lim Hae-Ri
Kim Haeng-Mi
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Abstract
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Purpose : The objective of this study was to establish the serum IGF-1 level in newborn infants, and investigate its association with growth and diseases.
Methods : In a retrospective study, serum IGF-1 levels were measured for newborn infants admitted to NICU at Kyungpook University Hospital from March 2 0 0 7 to July 2 0 0 7 . Birth data, disease history, and hospital course were obtained from medical records.
Results : Of 5 2 blood samples obtained at birth, serum IGF-l levels in 3 0 preterm infants (3 1 .6±2 7 .3 ng/ mL) were lower than in 2 2 full-term infants (5 3 .4±4 0 .0 ng/ mL; P<0 .0 5 ). In sick full-term infants, serum IGF-1 levels (4 6 .0±4 0 .2 ng/ mL) were lower than in healthy full-term infants (6 4 .1±3 9 .5 ng/ mL; P<0 .0 5 ). In preterm infants, there were no differences in IGF-1 levels between healthy (3 3 .2±2 3 .3 ng/ mL) and sick infants (3 0 .6±3 0 .4 ng/ mL); however, IGF-1 levels in both sick and healthy preterm infants were lower than in healthy full-term infants. Among infants admitted after 8 days of life, serum IGF-1 levels were higher in infants who gained weight (7 0 .8±3 6 .2 ng/ mL) than in infants who lost weight (1 3 .3±1 9 .9 ng/ mL; P<0 .0 1 ); however IGF-1 levels showed no difference between gender or method of delivery.
Conclusion : The study showed lower IGF-l levels in preterm infants than in full-term infants. Additionally, the IGF-l level in infants with weight loss was lower than in infants with weight gain. These results indicate that serum IGF-1 is associated with gestational age and postnatal growth.
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KEYWORD
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IGF-l, Infant, Premature, Full term, Newborn, Weight
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