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KMID : 1130320090520020199
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Korean Journal of Pediatrics
2009 Volume.52 No. 2 p.199 ~ p.204
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Inherited metabolic diseases in the urine organic acid analysis of complex febrile seizure patients
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Jung Hee-Jung
Kim Hye-Rim
Lee Seong-Soo
Bae Eun-Joo
Park Won-Il
Lee Hong-Jin
Choi Hui-Chul
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Abstract
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Purpose : Seizure associated with fever may indicate the presence of underlying inherited metabolic diseases. The present study was performed to investigate the presence of underlying metabolic diseases in patients with complex febrile seizures, using analyses of urine organic acids.
Method : We retrospectively analyzed and compared the results of urine organic acid analysis with routine laboratory findings in 2 7 8 patients referred for complex febrile seizure.
Results : Of 2 7 8 patients, 1 3 2 had no abnormal laboratory findings, and 1 4 6 patients had at least one of the following abnormal laboratory findings: acidosis (n=5 8 ), hyperammonemia (n=5 5 ), hypoglycemia (n=2 1 ), ketosis (n=1 2 ). Twenty-six (1 9 .7%) of the 1 3 2 patients with no abnormal findings and 1 0 4 (7 1 .2%) of the 1 4 6 patients with statistically significant abnormalities showed abnormalities on the organic acid analysis (P<0 .0 5 ). Mitochondrial respiratory chain disorders (n=2 3 ) were the most common diseases found in the normal routine laboratory group, followed by PDH deficiency (n=2 ) and ketolytic defect (n=1 ). In the abnormal routine laboratory group, mitochondrial respiratory chain disorder (n=2 9 ) was the most common disease, followed by ketolytic defects (n=2 7 ), PDH deficiency (n=9 ), glutaric aciduria type II (n=9 ), 3 -methylglutaconic aciduria type III (n=6 ), biotinidase deficiency (n=5 ), propionic acidemia (n=4 ), methylmalonic acidemia (n=2 ), 3 -hydroxyisobutyric aciduria (n=2 ), orotic aciduria (n=2 ), fatty acid oxidation disorders (n=2 ), 2 -methylbranched chain acyl CoA dehydrogenase deficiency (n=2 ), 3 -methylglutaconic aciduria type I (n=1 ), maple syrup urine disease (n=1 ), isovaleric acidemia (n=1 ), HMG-CoA lyase deficiency
(n=1 ), L-2 -hydroxyglutaric aciduria (n=1 ), and pyruvate carboxylase deficiency (n=1 ).
Conclusion: These findings suggest that urine organic acid analysis should be performed in all patients with complex febrile seizure and other risk factors for early detection of inherited metabolic diseases.
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KEYWORD
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Seizure, Febrile, Complex, Organic acid, Urine
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