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KMID : 1130320090520060713
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Korean Journal of Pediatrics
2009 Volume.52 No. 6 p.713 ~ p.716
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Facial palsy as the presenting symptom of acute myeloid leukemia in children: Three cases with stem cell transplantatio
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Baek Hee-Jo
Han Dong-Kyun
Kim Young-Ok
Choi Ic-Sun
Kook Hoon
Hwang Tai-Ju
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Abstract
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Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI, the patients underwent stem cell transplantations (SCTs). Two patients remain event-free 52 months and 62 months after allotransplants. Facial palsy was the harbinger of leukemic relapse in one case after autotransplant. This patient is disease-free 59 months after unrelated SCT rescue. Facial palsy persisted in 2 cases. Allogeneic SCT without WBI may be an effective therapy in patients presenting with facial palsy. A brief review of the literature is presented here.
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KEYWORD
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Facial palsy, Acute myeloid leukemia, Whole brain irradiation, Stem cell transplantation, Children
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