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KMID : 1130320130560110465
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Korean Journal of Pediatrics
2013 Volume.56 No. 11 p.465 ~ p.473
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Prevalence of rotavirus genotypes in South Korea in 1989?2009: implications for a nationwide rotavirus vaccine program
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Than Van Thai
Kim Won-Yong
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Abstract
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The epidemiology of human group A rotavirus was analyzed by examining genotypic data acquired from
1989 to 2009 in South Korea. This information was derived from all the available published articles
on rotavirus studies in South Korea, retrieved from both the PubMed and KoreaMed databases. Four
common G types (G1, G2, G3, and G4) and three common P types (P[8], P[4], and P[6]) accounted
for approximately 93% and 99% of the rotavirus reports, respectively. The G9 type was frequently
detected after 2000, and because of this prevalence, it is considered to be the fifth most important G
type rotavirus after the G1?G4 genotypes. Less common G types of the virus such as G12, G11, and
G10 were detected in some geographic settings, and it is important to consider the context of these
subtypes and their epidemiological significance. The P[9] virus genotype was observed in the study
and has been discussed in many other studies; however, the P[3], P[10] and P[25] genotypes were
rarely detected in the epidemiological research. In general, the distributions of the G and P genotypes
showed temporal and geographical fluctuations, and a nationwide rotavirus vaccine program that
targeted these genotypes demonstrated effectiveness in protecting against the circulating rotavirus
strains. However, further analysis is needed to determine the true long-term effectiveness of these
vaccines; the analysis should also consider the unexpected effects of vaccinations, such as vaccineinduced
diseases, herd immunity, and changes in host susceptibilities.
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KEYWORD
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Rotavirus , G type , P type , Nationwide vaccine program
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