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KMID : 1130320130560110477
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Korean Journal of Pediatrics
2013 Volume.56 No. 11 p.477 ~ p.481
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Serological investigation of Ureaplasma urealyticum in Korean preterm infants
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Eun Ho-Seon
Lee Soon-Min
Park Min-Soo
Park Kook-In
Namgung Ran
Lee Chul
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Abstract
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Purpose: Ureaplasma colonization is related with perinatal complications in preterm infants. Little is
known about the difference in virulence among various Ureaplasma urealyticum serovars. The aim of
this study was to determine U. urealyticum serovars of preterm infants in order to assess whether any
of the serovars were associated with bronchopulmonary dysplasia (BPD).
Methods: Three hundred forty-four preterm infants with a gestational age less than 34 weeks
admitted to Gangnam Severance Hospital neonatal intensive care unit from July 2011 to December
2012 were included in this study. Tracheal and gastric aspirations were conducted on infants to confirm
Ureaplasma colonization. Ureaplasma colonization was confirmed in 9% of infants, of these, serovars
were determined by real-time polymerase chain reaction.
Results: A total of 31 infants (gestational age, 29.3±3.1 weeks; birth weight, 1,170±790 g) were U.
urealyticum positive. The Ureaplasma positive group treated for more days with oxygen and ventilation
than the negative group (P<0.05). Histologic chorioamnionitis and moderate to severe BPD were more
frequent in the Ureaplasma positive group than in the negative group (P<0.05). U. urealyticum isolates
were either found to be a mixture of multiple serovars (32%), serovar 9 alone or combined with other
serovars (39%), serovar 11 (26%), 2 (13%), 8 (10%), 10 (13%), and 13 (25%). No individual serovars
were significantly associated with moderate to severe BPD and chorioamnionitis.
Conclusions: This is the first study to describe the distribution of U. urealyticum serovars from Korean
preterm infants. Ureaplasma -colonized infants showed higher incidence of BPD and chorioamnionitis.
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KEYWORD
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Ureaplasma urealyticum , Serovar , Bronchopulmonary dysplasia
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