|
KMID : 1130320190620010036
|
|
Korean Journal of Pediatrics
2019 Volume.62 No. 1 p.36 ~ p.41
|
|
|
Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit
|
|
Kim Se-Jin
Kim Ga-Eun
Park Jae-Hyun
Lee Sang-Lak
Kim Chun-Soo
|
|
|
Abstract
|
|
|
Purpose: In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients.
Methods: A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU.
Results: There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for EOS was group B Streptococcus (GBS), implicated in 10 cases (22.2%), followed by Escherichia coli, implicated in 9 cases (20%). The frequency of gram-positive sepsis was higher in term than in preterm infants, whereas the rate of gram-negative infection was higher in preterm than in term infants (P<0.05). The overall mortality was 37.8% (17 of 45), and 47% of deaths occurred within the first 3 days of infection. There were significant differences in terms of gestational age (26.8 weeks vs. 35.1 weeks) and birth weight (957 g vs. 2,520 g) between the death and survival groups. After adjustments based on the difference in gestational age and birth weight between the 2 groups, gram-negative pathogens (odds ratio [OR], 42; 95% confidence interval [CI], 1.4?1,281.8) and some clinical findings, such as neutropenia (OR, 46; 95% CI, 1.3?1,628.7) and decreased activity (OR, 34; 95% CI, 1.8?633.4), were found to be associated with fatality.
Conclusion: The common pathogens found to be responsible for EOS in NICU patients are GBS and E. coli. Gram-negative bacterial infections, decreased activity in the early phase of infection, and neutropenia were associated with poor outcomes.
|
|
|
KEYWORD
|
|
|
Early-onset sepsis, Clinical features, Prognosis, Neonatal intensive care unit
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|