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KMID : 1130320190620080317
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Korean Journal of Pediatrics
2019 Volume.62 No. 8 p.317 ~ p.323
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Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016?2017 Korea National Health and Nutrition Examination Survey
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Lee Jung-Hyun
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Abstract
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Purpose: Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents.
Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016?2017); 1,256 males and females aged 10?18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at 10?11 years of age (both sexes), >7.7 mg/dL for males at 12?18 years of age and >5.7 mg/dL for females at 12?18 years of age. MetS was defined by the International Diabetes Federation criteria. Logistic regression analysis was used to analyze hyperuricemia-associated risk factors.
Results: The prevalence of hyperuricemia was 9.4% (male, 8.4%; female, 10.5%) (P<0.281). After adjusting for sociodemographic factors and health behaviors in multivariate analysis (model 1), the odds ratio (OR) for hyperuricemia of MetS was 3.05 (95% confidence interval [CI], 1.17?7.92; P=0.022). After adjusting for the same variables in model 1 plus obesity and all MetS components (model 2), only abdominal obesity was significant, and the OR for hyperuricemia was 3.38 (95% CI, 1.72?6.63; P<0.001) After adjusting for the same variables in model 1 plus body mass index (BMI) z scores and all MetS components except abdominal obesity (model 3), only BMI z scores was significant, and the OR for hyperuricemia was 1.59 (95% CI, 1.34?1.89; P<0.001).
Conclusion: MetS, abdominal obesity, and BMI z scores were CMRFs significantly associated with hyperuricemia in Korean children and adolescents. Therefore, attention should be paid to hyperuricemia in patients with obesity or MetS.
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KEYWORD
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Child, Adolescent, Hyperuricemia, Metabolic syndrome, Obesity
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