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KMID : 1130320190620100374
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Korean Journal of Pediatrics
2019 Volume.62 No. 10 p.374 ~ p.379
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The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis
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Jenabi Ensiyeh
Bashirian Saied
Khazaei Salman
Basiri Zohreh
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Abstract
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Purpose: This is meta-analysis evaluated the association between maternal prepregnancy body mass index and the risk of ADHD among the resulting offspring.
Methods: The search identified studies published through December 2018 in the PubMed, Web of Science, and Scopus databases. The odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CI) extracted from eligible studies were used as the common measure of association among studies.
Results: A significant association was found between overweight women and the risk of ADHD among children with the pooled HR and OR estimates (HR, 1.27 and 95% CI, 1.17?1.37; OR, 1.28 and 95% CI, 1.15?1.40, respectively). This association was significant between obese women and the risk of ADHD among children and adolescents with the pooled estimates of HR and OR (HR, 1.65 and 95% CI, 1.55?1.76; OR, 1.42 and 95% CI, 1.23?1.61).
Conclusion: The current epidemiological studies present sufficient evidence that prepregnancy overweight and obesity are significantly associated with an increased risk of ADHD among children and adolescents. These findings provide a new approach to preventing ADHD by controlling weight gain in the prenatal period, which should be considered by policymakers.
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KEYWORD
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Attention deficit disorder with hyperactivity, Body mass index, Pregnancy
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