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KMID : 1130620050010010076
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Journal of Clinical Neurology
2005 Volume.1 No. 1 p.76 ~ p.80
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Relationship Between Essential Tremor and Cerebellar Dysfunction According to Age
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Lim Eui-Seong
Jeong Seul-Ki
Seo Man-Wook
Woo Seong-Ryong
Jeong Suk-Young
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Abstract
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Background: The cerebellum and its neural circuitry have been assumed to play a major role in the pathophysiology of essential tremor (ET). In this study, we sought to find associations between ET and cerebellar dysfunction.
Methods: We performed tandem gait test in 41 ET patients and 44 age-matched controls. Investigators assessed tandem gait by counting the number of missteps during ten-step tandem walk and each subject repeated the trial three times.
Results: ET patients had a higher average and total numbers of missteps during tandem gait tests than control subjects (p<0.05). Sex-adjusted odds ratio of the association between tandem gait abnormality and ET was 3.40 (95% confidence intervals 1.06-10.85). According to age stratification, aged ET patients (age ≥70 years) showed significantly higher prevalence of tandem gait abnormality than young ones. Interaction terms determined by a likelihood ratio test was also statistically significant (p<0.05).
Conclusions: Dysfunction of cerebellar neural circuitry may be associated with the pathophysiological mechanism of ET. In addition, aging may be an important factor modifying the association.
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KEYWORD
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Essential Tremor, Tamdem gait, Cerebellum, Age
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