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KMID : 1130620060020040252
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Journal of Clinical Neurology
2006 Volume.2 No. 4 p.252 ~ p.257
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1α,25-Dihydroxyvitamin D3 Protects Dopaminergic Neurons in Rodent Models of Parkinson’s Disease through Inhibition of Microglial Activation
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Kim Joong-Seok
Ryu Seon-Young
Yun In-Jin
Kim Woo-Jun
Lee Kwang-Soo
Park Jeong-Wook
Kim Yeong-In
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Abstract
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Background: Recent studies have demonstrated the molecular basis of the immunomodulatory and anti- inflammatory activities of 1,25-dihydroxyvitamin D3(1,25-(OH)2D3). This hormone improves behavioral deficits and normalizes the nigral dopamine levels in animal models of Parkinson’s disease (PD).
Methods: We studied whether the administration of 1,25-(OH)2D3 would protect against 6-hydroxydopa (6-OHDA)- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury, and its potential regulatory effect on microglia activation.
Results: We found that 1,25-(OH)2D3 pretreatment significantly decreased 6-OHDA- and MPTP-induced dopaminergic neuronal loss in the substantia nigra pars compacta by preventing the activation of microglia. This observed neuroprotective effect in MPTP-treated mice that were given 1,25-(OH)2D3 may be attributable to inhibition of proinflammatory cytokine expression.
Conclusion: These results suggest that 1,25-(OH)2D3 is a potentially valuable neuroprotective agent; it may therefore be considered for the treatment of pathologic conditions of the central nervous system, such as PD, where inflammation-induced neurodegeneration occurs
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KEYWORD
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Vitamin D, Parkinson’s Disease, 6-hydroxydopa (6-OHDA), 1-methyl-4-phenyl-, 2, 3, 6-tetrahydropyidine (MPTP), Cytokine, Inflammation, Rat, Mouse
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