KMID : 1130620080040020094
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Journal of Clinical Neurology 2008 Volume.4 No. 2 p.94 ~ p.98
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Severe Episodic Memory Impairment in a Patient With Clinical Features Compatible With Corticobasal Degeneration
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Kim Sung-Kwan
Kang Do-Young Kim Jae-Woo Kim Sang-Ho Cha Jae-Kwan Park Kyung-Won
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Abstract
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Corticobasal degeneration (CBD) is a progressive neurodegenerative disorder characterized by asymmetric
parkinsonism associated with apraxia, cortical sensory loss, and alien-limb phenomenon. Neuropsychological testing
in patients with CBD typically shows deficits in executive functions, praxis, language, and visuospatial functioning,
but not in memory. We report a CBD patient with severely impaired memory function but relatively mild motor
symptoms. Detailed neuropsychological assessment showed significant verbal and visual memory deficits accompanied
by frontal executive dysfunctions. Our observations indicate that CBD can in rare cases present with severe episodic
memory impairment associated with frontal executive dysfunctions in the early stage of illness.
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KEYWORD
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Corticobasal degeneration, Episodic memory, PET
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