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KMID : 1130620160120040495
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Journal of Clinical Neurology
2016 Volume.12 No. 4 p.495 ~ p.501
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Early Electrodiagnostic Features of Upper Extremity Sensory Nerves Can Differentiate Axonal Guillain-Barre Syndrome from Acute Inflammatory Demyelinating Polyneuropathy
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Koo Yong-Seo
Shin Ha-Young
Kim Jong-Kuk
Nam Tai-Seung
Shin Kyong-Jin
Bae Jong-Seok
Suh Bum-Chun
Oh Jee-Young
Yoon Byeol-A
Kim Byung-Jo
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Abstract
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Background and Purpose: Serial nerve conduction studies (NCSs) are recommended for differentiating axonal and demyelinating Guillain-Barre syndrome (GBS), but this approach is not suitable for early diagnoses. This study was designed to identify possible NCS parameters for differentiating GBS subtypes.
Methods: We retrospectively reviewed the medical records of 70 patients with GBS who underwent NCS within 10 days of symptom onset. Patients with axonal GBS and acute inflammatory demyelinating polyneuropathy (AIDP) were selected based on clinical characteristics and serial NCSs. An antiganglioside antibody study was used to increase the diagnostic certainty.
Results: The amplitudes of median and ulnar nerve sensory nerve action potentials (SNAPs) were significantly smaller in the AIDP group than in the axonal-GBS group. Classification and regression-tree analysis revealed that the distal ulnar sensory nerve SNAP amplitude was the best predictor of axonal GBS.
Conclusions: Early upper extremity sensory NCS findings are helpful in differentiating axonal-GBS patients with antiganglioside antibodies from AIDP patients.
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KEYWORD
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Guillain-Barre syndrome, acute inflammatory demyelinating polyneuropathy, early diagnosis, electrodiagnosis, neural conduction
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