KMID : 1134120190220030491
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Journal of Breast Cancer 2019 Volume.22 No. 3 p.491 ~ p.496
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Primary Histiocytic Sarcoma Presenting as a Breast Mass: A Case Report
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Bang Seong-Sik
Kim Ye-Seul Chung Min-Sung Park Jeong-Seon Choi Yun-Young Shin Su-Jin
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Abstract
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Histiocytic sarcoma is a rare hematologic malignancy, with very few cases of primary histiocytic sarcoma of the breast described in English scientific literature. Herein, we describe a case of primary histiocytic sarcoma of the breast in a 75-year-old woman, with no clinical history of malignant tumors, who presented with a palpable solitary breast mass. Microscopically, the resected breast mass showed large pleomorphic cells, some multinucleated giant cells, and admixed inflammatory components. The pleomorphic tumor cells further showed a diffuse, noncohesive growth pattern, an abundant eosinophilic cytoplasm, and strong and diffuse immunoreactivity for cluster of differentiation (CD) 68 and CD163. Furthermore, a whole-body positron-emission tomography/computed tomography using deoxy-2-[18F]fluoro-D-glucose performed after surgery showed no other masses or lesions. After surgical excision, the patient was followed up, and no evidence of tumor recurrence or metastasis was noted.
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KEYWORD
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Breast, Histiocytes, Histiocytic sarcoma, True histiocytic lymphoma
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