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KMID : 1134820190480121440
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 12 p.1440 ~ p.1446
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Anti-Pancreatic Cancer Effect of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose in PANC-1 through Inhibition of CD44
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Bae Min-Seo
Kim Eun-Young
Kim Yoon-Hee
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Abstract
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Pancreatic cancer is currently the fifth leading cause of cancer-related mortality in South Korea in 2017. 1,2,3,4,6-Penta-O-galloyl-β-D-glucose (PGG) is a gallotannin isolated from plants such as Galla Rhois. PGG has an anti-allergic effect, an anti-inflammatory effect and an inhibitory effect in colon cancer. However, the effect of PGG on pancreatic cancer cells remains unclear. Thus, this study evaluated the effect of PGG in pancreatic cancer, and its molecular mechanisms were evaluated. PGG inhibited cell proliferation and induced cytotoxicity. Further, PGG suppressed clonogenic activity, adhesion to fibronectin and migration. PGG inhibited the protein expression of the cluster of differentiation 44 (CD44), which is a marker of pancreatic cancer stem cells. PGG also suppressed the expression of Nanog, Oct-4, and Sox-2, which are factors for cancer stem cells and they are down stream of the CD44 signaling pathway. This data suggests that PGG is a potentially effective functional compound as therapy for pancreatic cancer.
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KEYWORD
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PGG, pancreatic cancer, CD44, cancer stem cell
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