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KMID : 1140120060110030248
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Cancer Prevention Research
2006 Volume.11 No. 3 p.248 ~ p.255
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Antitumor Effects of Chitosanoligossacharide Added Kimchi in Vivo
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Kim Boh-Kyung
Lee Sook-Hee
Kim So-Hee
Park Kun-Young
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Abstract
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Chitosanoligosaccharide (COS) was added to kimchi in order to increase antitumor and detoxification in sarcoma-180 transplanted Balb/c mouse. One % COS added kimchi in seasonings (COS-SK (1%)), 0.5% COS added kimchi in seasonings (COS-SK (0.5%)), 1% COS added kimchi in brine (COS-BK (1%)) and standardized kimchi (SK) were prepared. Kimchis were fermented at 15oC to reach optimum pH of 4.3. The antitumor activities of the COS added kimchi on Balb/c mice transplanted with the sarcoma-180 cell were investigated. The activities of liver enzyme, glutathione S-transferase (GST) and contents of glutathione (GSH) were determined from sarcoma-180 cell injected mice that were treated with methanol extracts from SK, COS-SK (1%), COS-SK (0.5%), COS-BK (1%) and COS itself. The tumor weight of SK, COS, COS-SK (1%), COS-SK (0.5%), COS-BK (1%) were 4.6 g, 3.3 g, 1.2 g, 1.8 g and 2.4 g, respectively. The activities of GST and the contents of GSH decreased by the transplantation of the sarcoma-180 cell were recovered considerably by the treatment of the methanol extract from COS-SK (1%), COS-SK (0.5%), COS-BK (1%) in the order. In conclusion, 1% COS added kimchi in seasonings exerted the strongest anticancer effect among the kimchi samples by inhibiting the tumor formation and controlling the activity of GST and contents of glutathione which were associated with the detoxification mechanism. These results suggest that COS added kimchi have a protective effect on the sarcoma-180 cell-induced hepatotoxicity in mice.
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KEYWORD
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Kimchi, Chitosanoligosaccharide, Sarcoma-180, Antitumor
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