|
KMID : 1140120080130030162
|
|
Cancer Prevention Research
2008 Volume.13 No. 3 p.162 ~ p.168
|
|
|
Overview on Molecular Mechanisms for the Preventive Effect of Antioxidants on the Protection Against Photoaging
|
|
Park Jee-Yeon
Seo Young-Rok
|
|
|
Abstract
|
|
|
|
Ultraviolet (UV)-induced aging has been reportedly accounted 80% of total aging process in human skin. Therefore, investigation on understanding the mechanism of UV-induced photoaging is essential for the prevention of skin aging. Mainly, the aging process induced by UV-generated ROS has been known to activate AP-1 factor, which stimulates several cellular pathways related with aging process including increase of inflammatory response, decrease of synthesis of dermal collagen I, III and inhibition for proliferation of keratinocyte. Recent studies have been suggested that several antioxidants, which play a role in remove ROS, have its own functions on prevention of photoaging. Furthermore, antioxidant has been reported to have potential role of increasing DNA repair activity, resulting in the removal of accumulated DNA damage. In this paper, molecular mechanisms in detail will be reviewed for the preventive effect of antioxidants on the protection against photoaging in human skin. (Cancer Prev Res 13, 162-168, 2008)
|
|
|
KEYWORD
|
|
|
Photoaging, ROS, Antioxidant
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|