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KMID : 1140120080130030184
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Cancer Prevention Research
2008 Volume.13 No. 3 p.184 ~ p.188
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1-methyl-4-phenylpyridinium Ion Induces the Apoptosis in HeLa Human Cervical Cancer Cells
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Ahn Kook-Hee
Kim Jung-Hye
Ahn Hee-Kyung
Jeong Joo-Won
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Abstract
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1-methyl-4-phenylpyridinium ion (MPP＋) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP＋ stimulates the production of reactive oxygen species (ROS) and induces dopaminergic neuronal cell death in vitro. In the present study, we investigated the apoptotic effects of MPP＋ in HeLa cells not dopaminergic neuronal cells. We found that MPP＋ induced the cell death and apoptosis in HeLa cells. Moreover, MPP＋ also increased the intracellular ROS in HeLa cells having similar pattern of dopaminergic cells. Taken together, these results demonstrate that MPP＋ induces apoptosis of human cervical cancer cells mediated by ROS generation. (Cancer Prev Res 13, 184-188, 2008)
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KEYWORD
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MPP＋, ROS, Apoptosis, HeLa cells
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