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KMID : 1140120080130040271
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Cancer Prevention Research
2008 Volume.13 No. 4 p.271 ~ p.275
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Inhibition of Vascular Network Formation on Human Microvessel Endothelial Cell by Betaine
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Yi Eui-Yeun
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Abstract
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Angiogenesis, the sprouting and remodeling of capillaries, plays a central role in a variety of physiologic and pathologic processes. Anti-angiogenesis therapy has recently been found to be one of the most promising new anti-cancer therapeutic strategies. Natural products comprise a major source of small molecular weight angiogenesis inhibitors. Angiogenesis and inflammation often share common pathways, and these two biological processes are also closely coupled with cancer. Both angiogenesis and inflammation are exacerbated by increased production of cytokines, growth factors and proteolytic enzymes. Betaine has been shown to have anti-inflammatory effects. In this study, we investigated the possibility that betaine inhibit angiogenesis. Therefore, we examined the effect of betaine on the vascular network formation of HMEC-1. Although betaine does not show any effect on the viability of HMEC-1, the treatment of betaine inhibited the tube formation of human microvessel endothelial cells (HMEC-1). This result suggests that betaine act for an angiogenic inhibitor.
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KEYWORD
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Angiogenesis, Inflammation, Tumor, Betaine, Natural products
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