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KMID : 1140120090140030242
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Cancer Prevention Research
2009 Volume.14 No. 3 p.242 ~ p.247
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The Effect of L-Arginine on Antioxidant Activity and Melanogenesis in Murine Melanoma Cells
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Song Kyung-Hee
Kim An-Keun
Yu Ji-Sun
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Abstract
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Pigmentation protects cells from harmful effects of sunlight or oxidative stress. It is due to the synthesis and dispersion of melanin. Our study has shown to melanogenesis effect of L-arginine on B16F10 cells, murine melanoma cells. L-arginine (0∼200 mM) exhibited effective cell growth inhibition dosedependently. L-arginine decrease level of ROS (reactive oxygen species). Further investigation revealed that L-arginine is a factor of melanogenesis. tyrosinase activity and Melanin contents increased dose dependent manner. Taken together, these findings suggest that L-arginine has to decrease the level of ROS, and increase tyrosinase activity and melanogenesis.
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KEYWORD
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L-Arginine, Antioxidant activity, Melanogenesis, Murine melanoma cells, ROS
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