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KMID : 1140120100150040257
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Cancer Prevention Research
2010 Volume.15 No. 4 p.257 ~ p.261
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Hepatic Failure Caused by High-dose Steroid in a Patient with Lymphoma
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Kim Moon-Jin
Kang Myoung-Hee
Kim Hoon-Gu
Kang Jung-Hun
Lee Gyeong-Won
Park Kyung-Bum
Lee Won-Sup
Jung Jin-Myung
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Abstract
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Glucocorticoid (GC) is widely used as an anti-emetic drug, an anti-inflammatory drug, or a pain killer for cancer patients. Though only a few cases of GC-induced hepatopathy were reported, the clinical course were mild and reversible, and the GC has also been used for the treatment of autoimmune hepatitis. Here, we found a case of fatal hepatic failure in a 52-year-old man with relapsed diffuse large B-cell lymphoma following high-dose glucocorticoid. Computed tomography (CT) scan revealed shrinkage of liver volume and large amount of ascites, indicating the aggravation of liver cirrhosis. The laboratory finding was consistent with hepatic failure: high bilirubin and prolonged prothrombin time. The patient died of hepatic failure and sepsis. Here, we discussed the mechanism of glucocorticoid-induced hepatopathy and proposed a new hypothesis on the glucocorticoid-induced hepatic failure in the patient with underlying liver disease.
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KEYWORD
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Glucocorticoid, Hepatic failure, Diffuse large B-cell lymphoma
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