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KMID : 1140120100150040262
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Cancer Prevention Research
2010 Volume.15 No. 4 p.262 ~ p.267
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Effects of Jeju Water Containing Vanadium on Antioxidant Enzymes in vitro
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Kim A-Reum
Kang Kyoung-Ah
Zhang Rui
Piao Mei Jing
Kim Suh-Kmann
Jee Young-Heun
Lee Nam-Ho
You Ho-Jin
Ko Kyoung-Soo
Hyun Jin-Won
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Abstract
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Recently, we reported that Jeju water containing vanadium exhibited an antioxidant effect via the scavenging of reactive oxygen species (ROS). In the present study, the aim was to examine the antioxidant effect of Jeju water containing vanadium (S3, 26.0±?2.0 μg/l) in terms of antioxidant enzymes in vitro. Human Chang liver cells were incubated for 10 passages in media prepared with either deionized distilled water (DDW) or S3. S3 increased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and heme oxygenase-1 (HO-1) compared to DDW. S3 also increased the level of reduced glutathione (GSH) shown by colorimetric assay and by high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy. These results suggest that vanadium-containing Jeju water (S3) produces antioxidant effect in vitro by enhancing antioxidant enzyme activities.
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KEYWORD
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Vanadium, Antioxidant effect, Antioxidant enzyme
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