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KMID : 1140120110160020155
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Cancer Prevention Research
2011 Volume.16 No. 2 p.155 ~ p.160
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Effects of β-lapachone on the Production of Inflammatory Cytokines in Mice
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Choi Myung-Won
Park In-Dal
Park Kun-Young
Kim Kwang-Hyuk
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Abstract
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β-Lapachone (1,2-naphthoquinone; β-lap) was originally isolated from the bark of the Lapacho tree, and its derivatives have been shown to exhibit a number of pharmacologic actions, including antiviral, antiparasitic, and antitumor activities. In the present study, we investigated the effects of β-lap on the production of cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interferon-γ (IFN-γ) in mice. The culture supernatants of mice splenocytes exposed with cell stimulants (LPS, ConA) alone or β-lap plus lipopolysaccharide (LPS), concanavalin A (Con A) were subjected to assay TNF-α, IL-6, and IFN-γ. TNF-α and IL-6 levels were lower and IFN-γ levels were higher in the culture supernatants of mice splenocytes exposed to Con A＋β-lap than those of the groups exposed to ConA alone. These findings demonstrate that β-lap downregulates the inflammatory cytokines immune responses by TNF-α, IL-6 and upregulates anti-inflammatory cytokine by IFN-γ in allergy-associated immunity. These results suggest that β-lap may have a potential for preventive or adjunct antiinflammatory therapy by modulating the production of cytokines. However, further in vivo investigation of this compound’s activity is necessary to elaborate its mechanisms.
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KEYWORD
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β-Lapachone, IL-6, TNF-α, IFN-γ
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