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KMID : 1140120110160030231
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Cancer Prevention Research
2011 Volume.16 No. 3 p.231 ~ p.237
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Jeju Ground Water Attenuates Adipogenesis in 3T3-L1 Preadipocytes
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Park Seon-Joo
Hyun Jin-Won
You Ho-Jin
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Abstract
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To investigated the inhibitory effect of Jeju ground water on adipogenesis, 3T3-L1 preadipocyte cells were cultured and differentiated in media made by Jeju ground water and deionized water (DW) containing a mixture of dexamethasone, isobutylmethylxanthine (IBMX) and insulin. Oil Red O staining showed that lipid accumulation attenuated in adipocyte cells treated with Jeju ground water. The mRNA expression levels of peroxisome-activated receptorγ (PPARγ) and CCAAT-enhancer binding proteinα (C/EBPα), which are a key components of the transcriptional control of adipogenesis, were decreased on adipocyte expose to Jeju ground water. Furthermore, the mRNA expression levels of target genes of these factors, such as adipocyte fatty acid (aP2), lipoprotein lipase (LPL) and Leptin, were also decreased by Jeju ground water treatment compared with control water. These results suggest that Jeju ground water containing vanadium components suppressed 3T3-L1 adipocyte differentiation
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KEYWORD
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Jeju ground water, Adipogenesis, Adipocyte differentiation, Lipid
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