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KMID : 1141920180340020088
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Annals of Coloproctology
2018 Volume.34 No. 2 p.88 ~ p.93
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Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer
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Kim Han-Jo
Baek Moo-Jun
Kang Dong-Hyun
Lee Sang-Cheol
Bae Sang-Byung
Lee Kyu-Taek
Lee Nam-Su
Kim Hyung-Joo
Jeong Dong-Jun
Ahn Tae-Sung
Lee Moon-Soo
Hong Dae-Sik
Won Jong-Ho
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Abstract
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Purpose: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. However, the clinical significance of lymphangiogenesis in patients with colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC.
Methods: A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC at Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined using immunohistochemistry. The expression of c-Met and clinical factors were analyzed.
Results: Of the 379 tissues, 301 (79.4%) had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P < 0.001) and VEGFR-3 (P = 0.001). However, no statistically significant association with podoplanin (P = 0.587) or VEGF-D (P = 0.096) was found. Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). However, no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), or overall survival (P = 0.360) was found.
Conclusion: Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers, but c-Met expression in patients with CRC is not a prognostic indicator for overall survival.
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KEYWORD
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Lymphangiogenesis, c-Met, Colorectal neoplasms
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