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KMID : 1141920200360040273
Annals of Coloproctology
2020 Volume.36 No. 4 p.273 ~ p.280
Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery
Oh Chang-Kyu

Huh Jung-Wook
Lee You-Jin
Choi Moon-Suk
Pyo Dae-Hee
Lee Sung-Chul
Park Seong-Mun
Shin Jung-Kyong
Park Yoon-Ah
Cho Yong-Beom
Yun Seong-Hyeon
Kim Hee-Cheol
Lee Woo-Yong
Abstract
Purpose: The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups.

Methods: From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I?III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The diseasefree survival rates of surgery-related postoperative complication groups were also compared.

Results: Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392).

Conclusion: Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.
KEYWORD
Postoperative complications, Colorectal cancer surgery, Risk factor, Recurrence
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