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KMID : 1142020210560040322
Blood Research
2021 Volume.56 No. 4 p.322 ~ p.331
Real-life ruxolitinib experience in intermediate-risk myelofibrosis
Arikan Fatma

Toptas Tayfur
Atagunduz Isik Kaygusuz
Ercan Tarik
Oruc Ozen
Yilmaz Fergun
Tuglular Tulin
Abstract
Background: In this retrospective cohort of patients with primary, post-polycythemia vera, or post-essential thrombocythemia myelofibrosis, 57 patients with MF who received ruxolitinib for MF-related symptoms or symptomatic splenomegaly were evaluated.

Methods: The median age of the patients in this cohort was approximately 58 years. Of these, there were 33 patients (57.9%) in INT-1, 23 patients (40.4%) in INT-2, and 1 patient (1.8%) at high risk. Overall, spleen size reduction of at least 35% (spleen response) was achieved in 56.6% and 63.3% of all cohort and INT-1 risk at any time, respectively.

Results: Symptom response and clinical improvement were observed in 21.7% and 60.7% of patients, respectively. Anemia and thrombocytopenia were prevalent, but manageable. About 73.7% of patients continued treatment during a median follow-up of 22 months. Two-year OS probability was approximately 84.5% (95% CI, 63.1?94.0%) and 62.3% (95% CI, 37.5?79.6%) for the intermediate-1 and -2 risk groups, respectively.

Conclusion: Real-life experience in a community-based hospital confirms the efficacy and safety profile of ruxolitinib in intermediate-risk myelofibrosis. Treatment discontinuation rates were lower than those in clinical trials.
KEYWORD
Primary myelofibrosis, Ruxolitinib, Spleen response
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