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KMID : 1142020230580040166
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Blood Research
2023 Volume.58 No. 4 p.166 ~ p.172
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Recent advances in cellular immunotherapy for lymphoid malignancies
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Chung Hae-Rim
Cho Hyun-Soo
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Abstract
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Cellular immunotherapy with chimeric antigen receptor (CAR) T-cells has revolutionized the treatment of lymphoid malignancies. This review addresses the need for CAR expression in our endogenous T-cells to kill tumor cells with a focus on the basic principles of T-cell receptor recognition of major histocompatibility complex-peptide complexes. We review the factors associated with CAR T-cell outcomes and recent efforts to employ CAR T-cells in earlier lines of therapy. We also discuss the value of bispecific T-cell engagers as off-the-shelf products with better toxicity profiles. Finally, natural killer cells are discussed as an important cellular immunotherapy platform with the potential to broaden immunotherapeutic applications beyond lymphoid malignancies.
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KEYWORD
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Cellular immunotherapy, Chimeric antigen receptor T cells, Lymphoma, Multiple myeloma
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