|
KMID : 1142720210240030083
|
|
Annals of Clinical Microbiology
2021 Volume.24 No. 3 p.83 ~ p.96
|
|
|
Evaluation of Five Automated Urine Analyzers as Screening Instruments for Enhancing Diagnostic Efficiency in Urinary Tract Infection
|
|
Cho Joo-Young
Byun Jung-Hyun
Lee Sang-Guk
Oh Kyeong-Jin
Jeon Beom-Chan
Yong Dong-Eun
Kim Jeong-Ho
|
|
|
Abstract
|
|
|
Background: Although urine culture is considered a reference standard for the diagnosis of urinary tract infection (UTI), it is time-consuming, labor-intensive, and expensive. Here, we evaluated the performance of five recent automated urine analyzers for UTI diagnosis.
Methods: For the 510 specimens analyzed, the criterion for ‘significant bacteriuria’ was defined as ≥ 104 CFU/mL in the inoculated plate for all specimens or ≥ 103 CFU/mL for specimens from patients using a Foley catheter or with urinary symptoms. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of UTI were analyzed using indicators individually, in different combinations, or with various cut-off values.
Results: Seventy-one specimens (13.9%) exhibited ‘significant bacteriuria’. In the receiver operating characteristics curve analysis, UF-5000 (Sysmex Corp., Japan) showed the highest area under the curve values for both males and females (0.876 and 0.846, respectively). The PPVs for specimens from males with all indicators positive increased up to 100% after adjusting the cut-off values. NPVs for specimens with all indicators negative were 94.3%?98.2% in males and 78.1%?93.8% in females after adjusting the cut-off values.
Conclusion: As a rapid and accurate diagnostic tool, urine sediment analyzers can be valuable for UTI diagnosis by reducing unnecessary culture and can help clinicians determine a treatment plan.
|
|
|
KEYWORD
|
|
|
Automated urine analyzer, Screening test, Urine culture, Urinary tract infections
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|