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KMID : 1143120120020030203
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Asia Pacific Allergy
2012 Volume.2 No. 3 p.203 ~ p.209
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Recent progress of elucidating the mechanisms of drug hypersensitivity
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Hashizume Hideo
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Abstract
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Recent technical approaches to investigating drug hypersensitivity have provided a great deal of information to solve the mechanisms that remain poorly understood. First, immunological investigations and in silico analysis have revealed that a novel interaction between T cells and antigen-presenting cells, namely the pharmacological interaction concept, is involved in drug recognition and the hapten theory. Second, progress in immunology has provided a new concept of CD4+ T cell subsets. Th17 cells have proven to be a critical player in acute generalized exanthematous pustulosis. Our recent findings suggest that this subset might contribute to the pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis. Third, alarmins, molecules associated with innate immunity, are also associated with exaggeration and the persistence of severe drug hypersensitivity. The latest innovative techniques are providing a new landscape to examine drug hypersensitivity.
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KEYWORD
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Allergy, Drug hypersensitivity, Human herpesvirus-6, Innate immunity, T cell, T cell receptor
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