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KMID : 1143120130030030186
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Asia Pacific Allergy
2013 Volume.3 No. 3 p.186 ~ p.193
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T cell transcriptional factors in allergic rhinitis and its association with clinical features
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Mo Ji-Hun
Chung Young-Jun
Kim Ji-Hye
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Abstract
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Background: Th2 cells are crucially important in allergic disease and the possible involvement of Treg and Th17 cells has not been clearly identified.
Objective: To identify the mRNA expression of T cell transcription factors in nasal mucosa in patients with allergic rhinitis (AR) and to reveal their correlations with clinical features.
Methods: Eighteen patients with AR and 12 controls with turbinate hypertrophy were included. mRNA expression of the following transcriptional factors in nasal mucosa were measured by quantitative polymerase chain reaction; T-bet (Th1), GATA3 (Th2), retinoic acid-related orphan receptor C (RORC; Th17), and forkhead box P3 (Foxp3; Treg). mRNA expression was compared among groups and correlation between mRNA expression level and clinical features (rhinitis symptoms, eosinophil count, and IgE) were also investigated.
Results: GATA3 and RORC were significantly increased and Foxp3 was significantly decreased in the AR group. Moderate-to-severe AR group also had increased expression of GATA3 and RORC than mild AR group, suggesting severity of AR influence expression of transcription factors. Correlation analysis showed that none of these transcription factors were associated with severity of clinical symptoms, eosinophil counts and skin prick test severity and that IgE level was significantly correlated with expression level of GATA3 and RORC, suggesting an association of IgE production with Th2 and Th17 cells.
Conclusion: Increased mRNA expression of GATA3 (Th2), increased expression of RORC and decreased expression of Foxp3 may be important in pathogenesis of AR. GATA3 and RORC may be closed related with IgE level.
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KEYWORD
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Allergic rhinitis, Transcription factor, T-bet, GATA3, Retinoic acid-related orphan receptor C, Forkhead box P3
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