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KMID : 1143120140040010068
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Asia Pacific Allergy
2014 Volume.4 No. 1 p.68 ~ p.72
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Rapid onset of Stevens-Johnson syndrome and toxic epidermal necrolysis after ingestion of acetaminophen
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Kim Eun-Jin
Lim Hyun
Park So-Young
Kim Su-Jeong
Yoon Sun-Young
Bae Yun-Jeong
Kwon Hyouk-Soo
Cho You-Sook
Moon Hee-Bom
Kim Tae-Bum
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Abstract
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but life-threatening, severe cutaneous adverse reactions most frequently caused by exposure to drugs. Several reports have associated the use of acetaminophen with the risk of SJS or TEN. A typical interval from the beginning of drug therapy to the onset of an adverse reaction is 1-3 weeks. A 43-year-old woman and a 60-year-old man developed skin lesions within 3 days after administration of acetaminophen for a 3-day period. Rapid identification of the symptoms of SJS and TEN caused by ingestion of acetaminophen enabled prompt withdrawal of the culprit drug. After administration of intravenous immunoglobulin G, both patients recovered fully and were discharged. These two cases of rapidly developed SJS/TEN after ingestion of acetaminophen highlight the possibility that these complications can develop within only a few days following ingestion of over-the-counter medications such as acetaminophen.
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KEYWORD
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Stevens-Johnson syndrome, Toxic epidermal necrolysis, Drug, Hypersensitivity, Acetaminophen
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